University of Alaska Anchorage
Chemistry Department

Dr. Eric G. Holmberg

Eric G. Holmberg, Ph.D. is a biochemist who studies the transformation of cells of the central nervous system using specific drug delivery vehicles, the effects of migration on the physiology of Pacific Salmon, therapeutic drug delivery systems: drug delivery by target-sensitive and pH-sensitive immunoliposomes, immunochemistry of drug delivery, proton flux in renal membrane vesicles, physical interaction of organic pH sensitive molecules with artificial and biological transport in renal membrane vesicles, and the binding of water transport inhibitors to red blood cell membranes, just to mention a few interests. Dr. Holmberg has published several peer-reviewed articles and has been teaching for over 20 years.

Contact Information
Eric G. Holmberg Telephone: 907-786-1289
Chemistry Department Fax: 907-786-4607
University of Alaska Anchorage E-mail: afegh@uaa.alaska.edu
3211 Providence Dr. Office: ENGR 305
Anchorage, AK 99508

Curriculum Vitae Contents


Education

Ph.D. Biophysical Chemistry - 1987


SUNY, Binghamton





B.S. Biochemistry - 1983


Niagara University, Lewiston, NY
Honors
Nominated for the National Science Foundation, Presidential Young Investigators Award, 1989


Research Exchange Scientist, National Institutes of Health, National Heart, Lung, and Blood Institute, US-USSR Cardiovascular Research exchange.

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Experience
8/94 - Present University of Alaska Anchorage, Department of Chemistry/Physics
Associate Professor of Chemistry with tenure
Current Department Chairperson


Teaching Responsibilities include Survey of Chemistry, Introduction to Organic and Biochemistry, General Chemistry, Organic Chemistry, Biochemistry, Advanced Biochemistry, Biophysical Chemistry. Research interests include the transformation of cells of the central nervous system using specific drug delivery vehicles, the effects of migration on the physiology of Pacific Salmon, therapeutic drug delivery systems: drug delivery by target-sensitive and pH-sensitive immunoliposomes, immunochemistry of drug delivery, proton flux in renal membrane vesicles, physical interaction of organic pH sensitive molecules with artificial and biological transport in renal membrane vesicles, and the binding of water transport inhibitors to red blood cell membranes. Served as department chair from 1995 through 2001 and from 2004 through present.


6/95 - 8/95 University of Tennessee, Memphis
Department of Anatomy and Neurobiology, School of Medicine
Visiting Scientist


7/89 - 8/94 University of Alaska, Anchorage, Department of Chemistry/Physics
Assistant Professor of Biochemistry; Instructor for WAMI
Department Chairperson: ?


6/87 - 7/89 Department of Biochemistry, University of Tennessee
Knoxville, Tennessee
Post-doctoral Research Associate
Senior Investigator: Professor Leaf Huang


5/88 - 7/88 National Heart Lung and Blood Institute, National Institutes of Health, at the Cardiology Research Center. Laboratory for Enzyme Engineering, Moscow, USSR
Research Exchange Scientist
Professor and Head: Vladimir P. Torchillin


9/83 - 5/87 SUNY, Chemistry Department, Binghamton
Lecturer, Research Assistant, Teaching Assistant

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Background

Birthplace: North Tonawanda, New York October 28, 1961



Family: Married (Carlie Anne Holmberg) with two children (Kenneth George Holmberg and Mackenzie Howard Holmberg)


Professional

Biophysical Society

American Chemical Society


Interests

Music (guitar, banjo, mandolin, fiddle), Waterfowling, Hunting, Fishing, Photography, Camping, Hiking, Flying (Private Pilot)


Thesis
Ph.D.: "Permeability of Biological and Artificial Membranes Evaluated with Physico-chemical Probes."

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Publications

  1. Gregory A. Helms, Eldon E. Geisert, Eric G. Holmberg, and John A. Jane "Distribution of Immunoliposomes in the CNS." Submitted, 1997.
  2. Eldon E. Geisert, Jr., Jesse L. Owens, and Eric G. Holmberg "Transfecting Neurons and Glia in the Rat CNS Using Immunoliposomes." Neurosci. Let., 184, 1-4, 1995.
  3. H. Suda, E.G. Holmberg, H.O. Nornes, and T. Neuman "Expression of E2F1 and E1A Induces DNA Synthesis in Differentiated Neurons In Vitro and In Vivo." NeuroReport, 5, 1749-1751, 1994.
  4. Eric G. Holmberg, Quentin Reuer, Eldon Geisert, and Jesse Owens "Liposomal Delivery of Plasmid DNA to Glial Cells." Biochem. Biophys.Res. Com., 201(2), 888-893, 1994.
  5. Eric G. Holmberg, and Nathan Turner "Effects of Migration on Proton Transport and Na+/H+ Exchange in Vesicles Isolated from Sockeye Salmon (Oncorhyncus nerka) Kidneys" Biochem. Biophys. Res. Com., 186(1), 24-31, 1992.
  6. G.W. Kabalka, M.A. Davis, E.G. Holmberg, K. Maruyama, and L. Huang "Gadolinium-Labeled Liposomes Containing Amphiphilic Gd-DTPA Derivatives of Varying Chain Length: Targeted MRI Contrast Agents for the Liver" Mag. Res Imag., 3, 374-376, 1991.
  7. G.W. Kabalka, M.A. Davis, E.G. Holmberg, K. Maruyama, and L. Huang, "Gadolinium-Labeled Liposomes Containing Various Amphiphillic Gd-DTPA Derivatives: Targeted MRI Contrast Enhancement Agents for the Liver" Mag. Res. 9, 373-377, 1991.
  8. G.W. Kabalka, M.A. Davis, T.H. Moss, E. Buonocore, K. Hubner, E. Holmberg, K. Maruyama, and L. Huang, "Gadolinium-Labeled Liposomes Containing Various Amphiphillic Gd-DTPA Derivatives: Targeted MRI Contrast Enhancement Agents for the Liver" Mag. Res. in Med. 19, 406-415, 1991.
  9. Eric G. Holmberg, Kazuo Maruyama, Stephen Kennel, Alexander Klibanov, Vladimir Torchillin, Una Ryan, and Leaf Huang, "Target-Specific Binding of Immunoliposomes In Vivo" J. Lip. Res. 1(4), 403-416, 1990.
  10. Kazuo Maruyama, Eric Holmberg, Stephen Kennel, Alexander Klibanov, Vladimir Torchilin, and Leaf Huang, "Characterization of In Vivo Immunoliposome Targeting to Pulmonary Endothelium" J. Pharm. Sci. 79(11), 978-984, 1990.
  11. Eric G. Holmberg, Kazuo Maruyama, David C. Litzinger, Stephen Wright, Mark Davis, George W. Kabalka, Stephen J. Kennel, and Leaf Huang, "Highly Efficient Immunoliposomes Prepared with a Method which is Compatible with Various Lipid Compositions" Biochem. Biophys. Res. Comm., 165, No. 3, 1272-1278, 1989.
  12. Eric G. Holmberg, A.S. Verkman, and James A. Dix, "Mechanism of Acridine Orange Interaction with Phospholipids and Proteins in Renal Microvillus Vesicles" Biophys. Chem., 33, 245-256, 1989.
  13. G.W. Kabalka, M. Davis, E. Buonocore, K. Hubner, E. Holmberg, and Leaf Huang, "Gd-Labeled Liposomes Containing Paramagnetic Amphiphiles" Contrast Media Research Conference Proceedings, Sidney and Hamilton Island, Australia, October 7, 1989. (in press)
  14. Eric G. Holmberg and Leaf Huang, "pH-sensitive and Target-sensitive Immunoliposomes for Drug Targeting" in Liposomes in the Therapy of Infectious Diseases and Cancer, UCLA Symposia on Molecular and Cellular Biology, New Series, Volume 89, Editor, G. Lopez-Berestein & I. Fidler, Alan R. Liss, Inc., New York, NY (1988).

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Abstracts

  1. Eric G. Holmberg "Bioengineering in Alaska" Science in Society, University of Alaska Anchorage, November 4, 1996. (invited lecture)
  2. N.A. DelMar, E.G. Holmberg, Q.R. Reuer, J.L. Owens, and E.E. Geisert, Jr., "In Vitro and In Vivo Delivery of Plasmid DNA by pH Sensitive Immunoliposomes" Society for Neuroscience, 1994 Annual Meeting, Miami Beach,Florida, November 13, 1994.(abst., presentation)
  3. Eric G. Holmberg and Eldon Geisert " "Transfecting Neurons and Glia in the Rat CNS Using Immunoliposomes." National Meeting of the Spinal Cord Society, August 21, 1993.
  4. Eric G. Holmberg "Liposomal Delivery of Plasmid DNA to Cells of the Central Nervous System" National Meeting of the Spinal Cord Society, August 14, 1992.
  5. Eric G. Holmberg "Drug Delivery Vehicle Advancements" Regional Meeting of the Spinal Cord Society, Seattle, Washington, September 7, 1991.
  6. Eric G. Holmberg "Genetic Transformation of Cells of the Central Nervous System" Regional Meeting of the Spinal Cord Society, Denver, Colorado, July 14-15, 1991.
  7. Eric G. Holmberg, and Nathan Turner, "Effects of Migration on the Renal Epithelial Physiology of Sockeye Salmon" 42nd Arctic Science Conference, May 14-15, 1991, University of Alaska Fairbanks, Fairbanks, Alaska. (abst., presentation)
  8. Eric G. Holmberg, Una S. Ryan, Stephen J. Kennel, and Leaf Huang, "Antibody Mediated Liposome Targeting to Mouse Pulmonary Artery Endothelial Cells" Biophys. J. 55, 331a, 1989 (abst.)
  9. Eric G. Holmberg, Michael B. Singer, and James A. Dix, "Determination of Reflection Coefficient of Urea in Renal Brush Border Membrane Vesicles," Biophys. J. 51, 341a, (1987). (abst.)
  10. Eric G. Holmberg and James A. Dix, "Binding of Acridine Orange to Renal Brush Border Membrane Vesicles", 16th Northeast Regional Meeting of the American Chemical Society, June, 1986. (abst., presentation)
  11. Eric G. Holmberg and James A. Dix, "Acridine Orange Binding to Renal Brush Border Membrane Vesicles", Biophys. J. 49, 237a, (1986). (abst.)

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Grants
1990: Faculty Development Grant, University of Alaska Anchorage, January 1990, "Membrane transport properties in Pacific Salmon." $4,110.00

Biomedical Research Support Grant, University of Alaska Fairbanks, January 1990, "Regulation of pH in epithelial membranes isolated from Pacific Salmon." $2,200.00


1991: Alaska Science and Technology Foundation, March 1991, "Research and Development of a Birch Sap Products Industry in Alaska", awarded by M. Cameron, $20,000.00

University of Alaska Natural Resources Fund, March 1991, "Thermodynamic Analysis and Development of Birch Sap and Syrup Products from Alaskan Birch Stands", $11,500


1991 - 1993: Spinal Cord Society, "Cell Specific Targeting by Immunoliposomes in the CNS" October 1991-January 1993, $43,500


1993: Spinal Cord Society, "Cell Specific Targeting of Immunoliposomes to Neurons" May 1993-August 1993, $58,540


1994: Spinal Cord Society, "Cell Specific Targeting of Immunoliposomes to Neurons and Glia" January 1994-Present, $82,950, in collaboration with the Colorado State University and University of Tennessee.


1995: Spinal Cord Society, "Keratanase Delivery to Neurons" June 1995 to August 1995, $7,880.00.


1996: Spinal Cord Society, "Regeneration in Chronic Spinal Cord Injuries" May 1996 to August 1996, $60,060, in collaboration with the University of Virginia.

1997: Spinal Cord Society, "Regeneration in Chronic Spinal Cord Injuries, Immunoliposomes Combination Trials" May 1997 to August 1997, $13,500, in collaboration with the University of Alabama.


Total: $304,240

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Teaching

Survey of Chemistry (CHEM 103) This course is designed to provide health science and liberal arts students with a general overview of basic chemical concepts.

Introduction to Organic and Biochemistry (CHEM 104) This course is designed to provide health science and liberal arts students with a general overview of organic and biochemistry concepts.

General Chemistry (CHEM 105 - 106) This course covers all the basic concepts of chemistry.

Physical Chemistry: A Biological Orientation (CHEM 311) This course introduces the principles of physical chemistry to students primarily interested in the biochemical and biological aspects of chemistry.

Organic Chemistry (CHEM 321 - 322) This course investigates the chemistry of carbon compounds and discusses physical properties, nomenclature, synthesis, reactions, mechanisms, stereochemistry, and spectroscopic identification of these compounds.

Biochemistry / Advanced Biochemistry (CHEM 441 - 442) The first semester of this course covers the structure and function of amino acids, proteins, carbohydrates, nucleic acids, lipis, and membranes. The second semester looks at the bioenergetics and metabolic pathways of these compounds.

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